Vitamin B12 deficiency.
Identifieur interne : 000058 ( Main/Exploration ); précédent : 000057; suivant : 000059Vitamin B12 deficiency.
Auteurs : Ralph Green [États-Unis] ; Lindsay H. Allen [États-Unis] ; Anne-Lise Bj Rke-Monsen [Norvège] ; Alex Brito [États-Unis] ; Jean-Louis Guéant [France] ; Joshua W. Miller [États-Unis] ; Anne M. Molloy [Irlande (pays)] ; Ebba Nexo [Danemark] ; Sally Stabler [États-Unis] ; Ban-Hock Toh [Australie] ; Per Magne Ueland [Norvège] ; Chittaranjan Yajnik [Inde]Source :
- Nature reviews. Disease primers [ 2056-676X ] ; 2017.
Abstract
Vitamin B12 (B12; also known as cobalamin) is a B vitamin that has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. Clinical B12 deficiency with classic haematological and neurological manifestations is relatively uncommon. However, subclinical deficiency affects between 2.5% and 26% of the general population depending on the definition used, although the clinical relevance is unclear. B12 deficiency can affect individuals at all ages, but most particularly elderly individuals. Infants, children, adolescents and women of reproductive age are also at high risk of deficiency in populations where dietary intake of B12-containing animal-derived foods is restricted. Deficiency is caused by either inadequate intake, inadequate bioavailability or malabsorption. Disruption of B12 transport in the blood, or impaired cellular uptake or metabolism causes an intracellular deficiency. Diagnostic biomarkers for B12 status include decreased levels of circulating total B12 and transcobalamin-bound B12, and abnormally increased levels of homocysteine and methylmalonic acid. However, the exact cut-offs to classify clinical and subclinical deficiency remain debated. Management depends on B12 supplementation, either via high-dose oral routes or via parenteral administration. This Primer describes the current knowledge surrounding B12 deficiency, and highlights improvements in diagnostic methods as well as shifting concepts about the prevalence, causes and manifestations of B12 deficiency.
DOI: 10.1038/nrdp.2017.40
PubMed: 28660890
Affiliations:
- Australie, Danemark, France, Inde, Irlande (pays), Norvège, États-Unis
- Californie, Colorado, Grand Est, Lorraine (région), New Jersey
- Nancy, New Brunswick (New Jersey)
- Université Rutgers
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Allen</name><affiliation wicri:level="2"><nlm:affiliation>USDA, ARS Western Human Nutrition Research Center, University of California Davis, Davis, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>USDA, ARS Western Human Nutrition Research Center, University of California Davis, Davis, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bj Rke Monsen, Anne Lise" sort="Bj Rke Monsen, Anne Lise" uniqKey="Bj Rke Monsen A" first="Anne-Lise" last="Bj Rke-Monsen">Anne-Lise Bj Rke-Monsen</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Brito, Alex" sort="Brito, Alex" uniqKey="Brito A" first="Alex" last="Brito">Alex Brito</name><affiliation wicri:level="2"><nlm:affiliation>USDA, ARS Western Human Nutrition Research Center, University of California Davis, Davis, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>USDA, ARS Western Human Nutrition Research Center, University of California Davis, Davis, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gueant, Jean Louis" sort="Gueant, Jean Louis" uniqKey="Gueant J" first="Jean-Louis" last="Guéant">Jean-Louis Guéant</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UMRS 954 N-GERE (Nutrition Génétique et Exposition aux Risques Environnementaux), University of Lorraine and INSERM, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMRS 954 N-GERE (Nutrition Génétique et Exposition aux Risques Environnementaux), University of Lorraine and INSERM, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Miller, Joshua W" sort="Miller, Joshua W" uniqKey="Miller J" first="Joshua W" last="Miller">Joshua W. Miller</name><affiliation wicri:level="4"><nlm:affiliation>School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region><settlement type="city">New Brunswick (New Jersey)</settlement></placeName><orgName type="university">Université Rutgers</orgName></affiliation></author><author><name sortKey="Molloy, Anne M" sort="Molloy, Anne M" uniqKey="Molloy A" first="Anne M" last="Molloy">Anne M. Molloy</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, University of Dublin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, University of Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Nexo, Ebba" sort="Nexo, Ebba" uniqKey="Nexo E" first="Ebba" last="Nexo">Ebba Nexo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Medicine, Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Medicine, Clinical Biochemistry, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Stabler, Sally" sort="Stabler, Sally" uniqKey="Stabler S" first="Sally" last="Stabler">Sally Stabler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Colorado Denver, Denver, Colorado, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Colorado Denver, Denver, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Toh, Ban Hock" sort="Toh, Ban Hock" uniqKey="Toh B" first="Ban-Hock" last="Toh">Ban-Hock Toh</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Inflammatory Diseases, Monash Institute of Medical Research, Clayton, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Inflammatory Diseases, Monash Institute of Medical Research, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Ueland, Per Magne" sort="Ueland, Per Magne" uniqKey="Ueland P" first="Per Magne" last="Ueland">Per Magne Ueland</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Yajnik, Chittaranjan" sort="Yajnik, Chittaranjan" uniqKey="Yajnik C" first="Chittaranjan" last="Yajnik">Chittaranjan Yajnik</name><affiliation wicri:level="1"><nlm:affiliation>Diabetes Unit, King Edward Memorial Hospital, Pune, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Diabetes Unit, King Edward Memorial Hospital, Pune, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature reviews. Disease primers</title><idno type="eISSN">2056-676X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vitamin B12 (B12; also known as cobalamin) is a B vitamin that has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. Clinical B12 deficiency with classic haematological and neurological manifestations is relatively uncommon. However, subclinical deficiency affects between 2.5% and 26% of the general population depending on the definition used, although the clinical relevance is unclear. B12 deficiency can affect individuals at all ages, but most particularly elderly individuals. Infants, children, adolescents and women of reproductive age are also at high risk of deficiency in populations where dietary intake of B12-containing animal-derived foods is restricted. Deficiency is caused by either inadequate intake, inadequate bioavailability or malabsorption. Disruption of B12 transport in the blood, or impaired cellular uptake or metabolism causes an intracellular deficiency. Diagnostic biomarkers for B12 status include decreased levels of circulating total B12 and transcobalamin-bound B12, and abnormally increased levels of homocysteine and methylmalonic acid. However, the exact cut-offs to classify clinical and subclinical deficiency remain debated. Management depends on B12 supplementation, either via high-dose oral routes or via parenteral administration. This Primer describes the current knowledge surrounding B12 deficiency, and highlights improvements in diagnostic methods as well as shifting concepts about the prevalence, causes and manifestations of B12 deficiency.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Danemark</li><li>France</li><li>Inde</li><li>Irlande (pays)</li><li>Norvège</li><li>États-Unis</li></country><region><li>Californie</li><li>Colorado</li><li>Grand Est</li><li>Lorraine (région)</li><li>New Jersey</li></region><settlement><li>Nancy</li><li>New Brunswick (New Jersey)</li></settlement><orgName><li>Université Rutgers</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Green, Ralph" sort="Green, Ralph" uniqKey="Green R" first="Ralph" last="Green">Ralph Green</name></noRegion><name sortKey="Allen, Lindsay H" sort="Allen, Lindsay H" uniqKey="Allen L" first="Lindsay H" last="Allen">Lindsay H. Allen</name><name sortKey="Brito, Alex" sort="Brito, Alex" uniqKey="Brito A" first="Alex" last="Brito">Alex Brito</name><name sortKey="Miller, Joshua W" sort="Miller, Joshua W" uniqKey="Miller J" first="Joshua W" last="Miller">Joshua W. Miller</name><name sortKey="Stabler, Sally" sort="Stabler, Sally" uniqKey="Stabler S" first="Sally" last="Stabler">Sally Stabler</name></country><country name="Norvège"><noRegion><name sortKey="Bj Rke Monsen, Anne Lise" sort="Bj Rke Monsen, Anne Lise" uniqKey="Bj Rke Monsen A" first="Anne-Lise" last="Bj Rke-Monsen">Anne-Lise Bj Rke-Monsen</name></noRegion><name sortKey="Ueland, Per Magne" sort="Ueland, Per Magne" uniqKey="Ueland P" first="Per Magne" last="Ueland">Per Magne Ueland</name></country><country name="France"><region name="Grand Est"><name sortKey="Gueant, Jean Louis" sort="Gueant, Jean Louis" uniqKey="Gueant J" first="Jean-Louis" last="Guéant">Jean-Louis Guéant</name></region></country><country name="Irlande (pays)"><noRegion><name sortKey="Molloy, Anne M" sort="Molloy, Anne M" uniqKey="Molloy A" first="Anne M" last="Molloy">Anne M. Molloy</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Nexo, Ebba" sort="Nexo, Ebba" uniqKey="Nexo E" first="Ebba" last="Nexo">Ebba Nexo</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Toh, Ban Hock" sort="Toh, Ban Hock" uniqKey="Toh B" first="Ban-Hock" last="Toh">Ban-Hock Toh</name></noRegion></country><country name="Inde"><noRegion><name sortKey="Yajnik, Chittaranjan" sort="Yajnik, Chittaranjan" uniqKey="Yajnik C" first="Chittaranjan" last="Yajnik">Chittaranjan Yajnik</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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